GeneTex
United States (US)

DC-SIGN antibody

GTX31657_1323_IHC-P_20180221_18121410_587.jpg
GTX31657_2836_WB_20180221_18121410_975.jpg

Cat No. GTX31657

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, ELISA
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 2 μg/mL
IHC-P 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Positive Control

Human Small Intestine Tissue Lysate(GTX27923) , Human Placenta Tissue Lysate(GTX29186) , Human Small Intestine Tissue Slide
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

DC-SIGN antibody was raised against a synthetic peptide corresponding to 17 amino acids near the center of human DC-SIGN.The immunogen is located within amino acids 250 - 300 of DC-SIGN.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cd209 Molecule,Cdsign,Clec4L,Dc-Sign,Dc-Sign1,Cd209

Background

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant i

Database

Research Area

DATA IMAGES
GTX31657_1323_IHC-P_20180221_18121410_587.jpg

GTX31657 IHC-P Image

IHC-P analysis of human small intestine tissue using GTX31657 DC-SIGN antibody.
Working concentration : 10 μg/ml

GTX31657_2836_WB_20180221_18121410_975.jpg

GTX31657 WB Image

WB analysis of human placenta tissue lysate in the absence (lane 1) and presence (lane 2) of blocking peptide using GTX31657 DC-SIGN antibody.
Working concentration : 2 μg/ml

Package List Price ($)
$ 329