DC-SIGN antibody

Cat. No. GTX31657

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P, ELISA
Reactivity	Human
Package	100 μg ($399)

See all DC-SIGN products

Datasheet
Document

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	2 μg/mL
IHC-P	10 μg/mL
ELISA	Assay dependent

Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Positive Control

Human Small Intestine Tissue Lysate(GTX27923) , Human Placenta Tissue Lysate(GTX29186) , Human Small Intestine Tissue Slide

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

DC-SIGN antibody was raised against a synthetic peptide corresponding to 17 amino acids near the center of human DC-SIGN.The immunogen is located within amino acids 250 - 300 of DC-SIGN.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD209 molecule , CDSIGN , CLEC4L , DC-SIGN , DC-SIGN1

Background

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant i

Database

Gene ID: 30835 CD209
UniProt: Q9NNX6 CD209

Research Area

DATA IMAGES

GTX31657 IHC-P Image

IHC-P analysis of human small intestine tissue using GTX31657 DC-SIGN antibody.
Working concentration : 10 μg/ml

GTX31657 WB Image

WB analysis of human placenta tissue lysate in the absence (lane 1) and presence (lane 2) of blocking peptide using GTX31657 DC-SIGN antibody.
Working concentration : 2 μg/ml

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SDS
PBS.pdf
Sodium Azide.pdf

Package

List Price ($)

100 μg

$ 399

Qty