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DC-SIGN antibody

Anti-DC-SIGN antibody used in IHC (Frozen sections) (IHC-Fr). GTX74430
Anti-DC-SIGN antibody used in Western Blot (WB). GTX74430

Cat No. GTX74430

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-Fr

Reactivity

Human, Sheep
Package
50 μg ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1μg/ml-2μg/ml
ICC/IF Assay dependent
IHC-Fr Assay dependent

Note :

WB
This antibody detects a band of approximately 44 kD by western blot.

Not tested in other applications.

Calculated MW

46 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.02% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to amino acids 277-293 of human DC-SIGN.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Cd209 Molecule , Cdsign , Clec4L , Dc-Sign , Dc-Sign1 , Cd209

Background

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant i

Database

Research Area

DATA IMAGES

Anti-DC-SIGN antibody used in IHC (Frozen sections) (IHC-Fr). GTX74430

GTX74430 IHC-Fr Image

IHC analysis of human small inestine tissue using GTX74430 DC-SIGN antibody.

Anti-DC-SIGN antibody used in Western Blot (WB). GTX74430

GTX74430 WB Image

WB analysis of human placenta tissue lysate using GTX74430 DC-SIGN antibody in the absence (lane 1) and presence (lane 2) of blocking peptide

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 329