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United States (US)

DC-SIGN peptide

Cat No. GTX26091

Application

 Neutralizing/Inhibition

Species

 Human
Package
50 μg ($139)
See all DC-SIGN products

APPLICATION

Application Note

The peptide is used for blocking the antibody activity of anti-CD209 (cat. No GTX25715). It usually blocks the antibody activity completely in Western blot by incubating the peptide with an equal volume of antibody for 30 min at 37ºC.

PROPERTIES

Form

Liquid

Buffer

PBS pH7.2, 10mM NaH₂PO₄, 10mM Na₂HPO₄, 130mM NaCl, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store the peptide at -20ºC, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Cd209 Molecule , Cdsign , Clec4L , Dc-Sign , Dc-Sign1 , Cd209

Background

Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DCSIGN (also termed CD209). ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DCSIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 139