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DCTN1 antibody [3D5-C6-D5]

Anti-DCTN1 antibody [3D5-C6-D5] used in Immunoprecipitation (IP). GTX49164
Anti-DCTN1 antibody [3D5-C6-D5] used in Western Blot (WB). GTX49164

Cat No. GTX49164

Host

Mouse

Clonality

Monoclonal

Clone Name

3D5-C6-D5

Isotype

IgG2b

Application

WB, IP

Reactivity

Human
Package
100 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

150 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified recombinant DCTN1 protein fragments expressed in E.coli

Purification

Affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Dynactin Subunit 1 , Dap-150 , Dp-150 , P135 , Dctn1

Cellular Localization

Cytoplasm

Background

This gene encodes the largest subunit of dynactin,a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150kD.Dynactin binds to both microtubules and cytoplasmic dynein.Dynactin is involved in a diverse array of cellular functions,including ER-to-Golgi transport,the centripetal movement of lysosomes and endosomes,spindle formation,chromosome movement,nuclear positioning, and axonogenesis.This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).[provided by RefSeq, Oct 2008]

Database

Research Area

DATA IMAGES

Anti-DCTN1 antibody [3D5-C6-D5] used in Immunoprecipitation (IP). GTX49164

GTX49164 IP Image

IP analysis of HeLa lysates using control IgG and Dynactin 1 antibody. The precipitates were detected by the same Dynactin 1 antibody.

Anti-DCTN1 antibody [3D5-C6-D5] used in Western Blot (WB). GTX49164

GTX49164 WB Image

WB analysis of indicated lysate using Dynactin 1 antibody at a dilution of 1:1,000.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf