Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Batch dependent (Please refer to the vial label for the specific concentration.)
Purified recombinant DCTN1 protein fragments expressed in E.coli
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Dynactin Subunit 1 , Dap-150 , Dp-150 , P135 , Dctn1
This gene encodes the largest subunit of dynactin,a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150kD.Dynactin binds to both microtubules and cytoplasmic dynein.Dynactin is involved in a diverse array of cellular functions,including ER-to-Golgi transport,the centripetal movement of lysosomes and endosomes,spindle formation,chromosome movement,nuclear positioning, and axonogenesis.This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).[provided by RefSeq, Oct 2008]