100 μl serum containing 0.02% sodium azide.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Death Effector Domain Containing 2 , Flame-3 , Flame3 , Dedd2
A novel Death Effector Domain-containing protein, DEDD2, is closest in amino acid sequence homology to Death Effector Domain-containing DNA-binding protein, DEDD. DEDD2 is expressed widely in adult human tissues with highest levels in liver, kidney and peripheral blood leukocytes. DEDD2 interacts with FLIP, but not with FADD or Caspase 8. Over-expression of DEDD2 induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas(CD95/APO-1), TRAIL(Apo2L), or FADD. These findings suggest that DEDD2 is involved in the regulation of nuclear events mediated by the extrinsic apoptosis pathway.