GeneTex

  • Country / Location Selection

United States (US)

DISC1 antibody, Internal

Anti-DISC1 antibody, Internal used in Western Blot (WB). GTX89158

Cat. No. GTX89158

Reference 1

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all DISC1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.1-0.3μg/ml
IHC Assay dependent
Not tested in other applications.

Calculated MW

94 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX89158-PEP).

Product Note

This antibody is expected to recognise isoforms L ( NP_061132.2) and Lv (NP_001012975.1) only.

PROPERTIES

Form

Liquid

Buffer

TBS, 0.5% BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence C-HSEDKRKTPLKVLE, from the internal region of the protein sequence according to NP_001012975.1; NP_061132.2.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

RRID

AB_10732766

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

DISC1 scaffold protein , C1orf136 , SCZD9

Cellular Localization

Cytoplasm , Cytoplasm, cytoskeleton , Mitochondrion

Background

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-DISC1 antibody, Internal used in Western Blot (WB). GTX89158

GTX89158 WB Image

WB analysis of human hippocampus lysate using GTX89158 DISC1 antibody, Internal.
Dilution : 0.1μg/ml
Loading : 35μg protein in RIPA buffer

REFERENCE

Application Reference

Katsel P et al. The Journal for Psychoses and Related Disorders 2017; (Epub) Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development.
Application : IHC
Reactivity : Mouse
Submit a Reference

REVIEW

There are currently no reviews for DISC1 antibody, Internal (GTX89158). Be the first to share your experience with this product.
Submit a Review
SDS
Sodium Azide.pdf
Package List Price ($)
$ 399