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DKK1 antibody

Anti-DKK1 antibody used in IHC (Paraffin sections) (IHC-P). GTX40056

Cat. No. GTX40056

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
50 μg ($459)
See all DKK1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000
IHC-P 10 μg/ml

Note :

IHC-P
Heat induced antigen retrieval in pH 6.0 citrate buffer
Not tested in other applications.

Calculated MW

29 kDa. ( Note )

Predict Reactivity

Monkey, Gibbon, Gorilla, Marmoset(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic 15 amino acid peptide from the cytoplasmic domain of human DKK1.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_1080967

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

dickkopf WNT signaling pathway inhibitor 1 , DKK1 , SK

Cellular Localization

Secreted

Background

This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]

Database

Research Area

DATA IMAGES

Anti-DKK1 antibody used in IHC (Paraffin sections) (IHC-P). GTX40056

GTX40056 IHC-P Image

IHC-P analysis of human uterus, endometrium tissue using GTX40056 DKK1 antibody.
Antigen retrieval : Heat-induced antigen retrieval

REFERENCE

Application Reference

Brockway HM et al. PLoS One 2019; 14 (11) : e0225062 Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births.
Application : IHC-P
Reactivity : Human
Heather M Brockway et al. bioRxiv 2018; (Epub) Assessing placental maturity through histological and transcriptomic analyses in idiopathic spontaneous preterm birth.
Application : IHC-P
Reactivity : Human
Submit a Reference

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 459