DLC1 antibody [C2C3], C-term

Name: DLC1 antibody [C2C3], C-term
Brand: GeneTex
SKU: GTX113607
Price: 399.00 USD
Rating: 5 (1 reviews)

Anti-DLC1 antibody [C2C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX113607

Anti-DLC1 antibody [C2C3], C-term used in Western Blot (WB). GTX113607

Cat. No. GTX113607

Reference 1

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P
Reactivity	Human, Mouse
Package	100 μl ($399), 25 μl ($169)

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View product citations for antibody GTX113607 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:500-1:3000
IHC-P	1:100-1:1000

Not tested in other applications.

Calculated MW

171 kDa. ( Note )

Positive Control

HepG2

Predict Reactivity

Rat, Bovine, Dog(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 20% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human DLC1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_11165839

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

DLC1 Rho GTPase activating protein , ARHGAP7 , HP , STARD12 , p122-RhoGAP

Cellular Localization

Cytoplasm

Background

This gene is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p22-p21.3, a region frequently deleted in solid tumors. It is suggested that this gene is a candidate tumor suppressor gene for human liver cancer, as well as for prostate, lung, colorectal, and breast cancers. Alternative splicing at this locus results in several transcript variants encoding different isoforms. [provided by RefSeq]

Database

Gene ID: 10395 DLC1
UniProt: Q96QB1 DLC1

Research Area

DATA IMAGES

GTX113607 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human breast cancer, using DLC1(GTX113607) antibody at 1:500 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

GTX113607 WB Image

Sample (30 ug of whole cell lysate)
A: HepG2
5% SDS PAGE
GTX113607 diluted at 1:1000

REFERENCE

Application Reference

Sanchez-Solana B et al. Mol Cancer 2021; 20 (1) : 141 The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1.

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