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DLK1 antibody

Anti-DLK1 antibody used in IHC (Paraffin sections) (IHC-P). GTX60309
Anti-DLK1 antibody used in Western Blot (WB). GTX60309
Anti-DLK1 antibody used in IHC (Paraffin sections) (IHC-P). GTX60309
Anti-DLK1 antibody used in Western Blot (WB). GTX60309

Cat. No. GTX60309

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, IHC-Fr

Reactivity

 Human, Mouse, Rat, Sheep
Package
100 μl ($419)
See all DLK1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:300-1000
IHC-P 1:50-400
IHC-Fr Assay dependent
Not tested in other applications.

Calculated MW

41 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

1% BSA, 50% Glycerol

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human DLK1(260-305).

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

delta like non-canonical Notch ligand 1 , DLK , DLK-1 , Delta1 , FA1 , PREF1 , Pref-1 , ZOG , pG2

Cellular Localization

Membrane; Single-pass type I membrane protein,Cytoplasm

Background

This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010]

Database

Research Area

DATA IMAGES

Anti-DLK1 antibody used in IHC (Paraffin sections) (IHC-P). GTX60309

GTX60309 IHC-P Image

IHC-P analysis of sheep fat tissue using GTX60309 DLK1 antibody.
Dilution : 1:200

Anti-DLK1 antibody used in Western Blot (WB). GTX60309

GTX60309 WB Image

WB analysis of sheep fat tissue lysate using GTX60309 DLK1 antibody.
Dilution : 1:200

Anti-DLK1 antibody used in IHC (Paraffin sections) (IHC-P). GTX60309

GTX60309 IHC-P Image

IHC-P analysis of mouse embryo tissue using GTX60309 DLK1 antibody.
Dilution : 1:200

Anti-DLK1 antibody used in Western Blot (WB). GTX60309

GTX60309 WB Image

WB analysis of HepG2 cell lysate using GTX60309 DLK1 antibody.
Dilution : 1:1000
The observed M.W. is based on the publication: PMID: 32205867

REFERENCE

Application Reference

O'Neill AM et al. Sci Transl Med 2022; 14 (632) : eabh1478 Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne.
Application : IHC-Fr
Reactivity : Human, Mouse
Tatsuya Dokoshi et al. J Clin Invest 2021; 131 (21) Skin inflammation activates intestinal stromal fibroblasts and promotes colitis.
Application : IHC-Fr
Reactivity : Mouse
Submit a Reference

REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 419