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DMPK antibody, Internal

Anti-DMPK antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX47067
Anti-DMPK antibody, Internal used in Western Blot (WB). GTX47067

Cat. No. GTX47067

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
50 μg ($409)
See all DMPK products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.2-2.5 ug/ml
IHC-P 2-10 ug/ml
Not tested in other applications.

Calculated MW

69 kDa. ( Note )

Positive Control

ACHN

PROPERTIES

Form

Liquid

Buffer

PBS, 2% Sucrose

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to an Internal region of Human DMPK

Purification

Affinity Purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

DM1 protein kinase , DM , DM1 , DM1PK , DMK , MDPK , MT-PK

Cellular Localization

Endoplasmic reticulum membrane,Nucleus outer membrane,Mitochondrion outer membrane,Cell membrane,Cytoplasm, cytosol

Background

The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]

Database

Research Area

DATA IMAGES

Anti-DMPK antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX47067

GTX47067 IHC-P Image

IHC-P analysis of human heart tissue using GTX47067 DMPK antibody at 5μg/ml.

Anti-DMPK antibody, Internal used in Western Blot (WB). GTX47067

GTX47067 WB Image

WB analysis of ACHN cells using GTX47067 DMPK antibody at 1μg/ml.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409