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DMPK antibody

Anti-DMPK antibody used in Western Blot (WB). GTX66672

Cat No. GTX66672

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB

Reactivity

Human, Mouse, Rat
Package
100 μl ($349)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:1000
Not tested in other applications.

Calculated MW

69 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.2, 0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to the N-terminus of Human DMPK.

Purification

Purified by antigen-affinity chromatography
From serum

Purity

> 95% (by SDS-PAGE)

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

DM1 protein kinase , DM , DM1 , DM1PK , DMK , MDPK , MT-PK

Cellular Localization

Endoplasmic reticulum membrane,Nucleus outer membrane,Mitochondrion outer membrane,Cell membrane,Cytoplasm, cytosol

Background

The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]

Database

Research Area

DATA IMAGES

Anti-DMPK antibody used in Western Blot (WB). GTX66672

GTX66672 WB Image

WB analysis of various samples using GTX66672 DMPK antibody.
Lane1 : CT26 whole cell lysate(40ug)
Lane2 : The Brain tissue lysate of Rat(40ug)
Lane3 : A549 whole cell lysate(40ug)
Lane4 : L02 whole cell lysate(40ug)
Lane5 : HEK293T whole cell lysate(20ug)
Dilution : 1:500

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 349