APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Dilution |
| 1:500-1:3000 |
Not tested in other applications.
Calculated MW
Positive Control
PC-3 , U87-MG , mouse testis
Predict Reactivity
Chicken, Rhesus Monkey(>80% identity)
PROPERTIES
Form
Liquid
Buffer
1XPBS (pH7), 1% BSA, 20% Glycerol
Preservative
0.01% Thimerosal
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant protein encompassing a sequence within the center region of human DMTF1. The exact sequence is proprietary.
Purification
Purified by antigen-affinity chromatography.
Conjugation
Unconjugated
RRID
AB_11167128
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
cyclin D binding myb like transcription factor 1 , DMP1 , DMTF , MRUL , hDMP1
Cellular Localization
Nucleus
Background
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Database
Research Area
DATA IMAGES
![Anti-DMTF1 antibody [N3C2], Internal used in Western Blot (WB). GTX112228](/templates/default/js/lightbox/images/loading.gif "Anti-DMTF1 antibody [N3C2], Internal used in Western Blot (WB). GTX112228")
|
GTX112228 WB Image
Sample (50 ug of whole cell lysate)
A: mouse testis
7.5% SDS PAGE
GTX112228 diluted at 1:1000
|
|
|
GTX112228 WB Image
Sample (30 ug of whole cell lysate)
A: PC-3
B: U87-MG
7.5% SDS PAGE
GTX112228 diluted at 1:1000
|
REFERENCE
There are currently no references for DMTF1 antibody [N3C2], Internal (GTX112228). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for DMTF1 antibody [N3C2], Internal (GTX112228). Be the first to share your experience with this product.
![Anti-DMTF1 antibody [N3C2], Internal used in Western Blot (WB). GTX112228](/upload/website/prouct_img/small/GTX112228/GTX112228_40814_WB_M_Testis_18121410_577.jpg "Anti-DMTF1 antibody [N3C2], Internal used in Western Blot (WB). GTX112228")
![Anti-DMTF1 antibody [N3C2], Internal used in Western Blot (WB). GTX112228](/upload/website/prouct_img/small/GTX112228/GTX112228_40814_WB_18121410_564.jpg "Anti-DMTF1 antibody [N3C2], Internal used in Western Blot (WB). GTX112228")
![Anti-DMTF1 antibody [N3C2], Internal used in Western Blot (WB). GTX112228](/upload/website/prouct_img/normal/GTX112228/GTX112228_40814_WB_M_Testis_18121410_577.jpg "Anti-DMTF1 antibody [N3C2], Internal used in Western Blot (WB). GTX112228")
![Anti-DMTF1 antibody [N3C2], Internal used in Western Blot (WB). GTX112228](/upload/website/prouct_img/normal/GTX112228/GTX112228_40814_WB_18121410_564.jpg "Anti-DMTF1 antibody [N3C2], Internal used in Western Blot (WB). GTX112228")