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DNMT1 antibody [DNMT1/2061]

Anti-DNMT1 antibody [DNMT1/2061] used in IHC (Paraffin sections) (IHC-P). GTX02546
Anti-DNMT1 antibody [DNMT1/2061] used in IHC (Paraffin sections) (IHC-P). GTX02546

Cat. No. GTX02546

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 DNMT1/2061

Isotype

 IgG2b

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($529)
See all DNMT1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2 μg/ml

Note :

IHC-P
Require heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes
Not tested in other applications.

Calculated MW

183 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human DNMT1 protein fragment (around aa 767-912).

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

DNA methyltransferase 1 , ADCADN , AIM , CXXC9 , DNMT , HSN1E , MCMT , m.HsaI

Cellular Localization

Nucleus

Background

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Database

Research Area

DATA IMAGES

Anti-DNMT1 antibody [DNMT1/2061] used in IHC (Paraffin sections) (IHC-P). GTX02546

GTX02546 IHC-P Image

IHC-P anaylsis of human placenta tissue using GTX02546 DNMT1 antibody [DNMT1/2061].

Anti-DNMT1 antibody [DNMT1/2061] used in IHC (Paraffin sections) (IHC-P). GTX02546

GTX02546 IHC-P Image

IHC-P anaylsis of human tonsil tissue using GTX02546 DNMT1 antibody [DNMT1/2061].

REFERENCE

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REVIEW

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Package List Price ($)
$ 529