*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
This antibody recognizes with mouse Dnmt3b isoforms 3b1, 3b2, 3b3 and 3b6, but does not react with Dnmt3a due to its immunogen.
PBS, 50% glycerol
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
~0.3 mg/ml (Please refer to the vial label for the specific concentration.)
Recombinant mouse Dnmt3b (amino acids 1-181)
Purified by antigen-affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
DNA methyltransferase 3B , MmuIIIB
This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]