0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Recombinant protein encompassing a sequence within the center region of human DR3. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
APO-3 antibody, DDR3 antibody, DR3 antibody, LARD antibody, TNFRSF12 antibody, TR3 antibody, TRAMP antibody, WSL-1 antibody, WSL-LR antibody, TNFRSF25 antibody, apoptosis-mediating receptor TRAMP antibody, tumor necrosis factor receptor superfamily member 25 antibody, death receptor beta antibody, protein WSL-1 antibody, apoptosis inducing receptor antibody, tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein) antibody, apoptosis-mediating receptor DR3 antibody, lymphocyte-associated receptor of death antibody, apoptosis-inducing receptor AIR antibody, death domain receptor 3 soluble form antibody, tumor necrosis factor receptor superfamily, member 25 antibody
Isoform 1: Cell membrane; Single-pass type I membrane protein , Isoform 2: Cell membrane; Single-pass type I membrane protein , Isoform 9: Cell membrane; Single-pass type I membrane protein , Isoform 11: Cell membrane; Single-pass type I membrane protein
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq]