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DR4 antibody [DR-4-02]

Anti-DR4 antibody [DR-4-02] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00590

Cat. No. GTX00590

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 DR-4-02

Isotype

 IgG1

Application

 ICC/IF, FACS, IP

Reactivity

 Human
Package
100 μg ($399)
See all DR4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
FACS Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.

Purification

Protein A purified

Conjugation

Unconjugated

RRID

AB_2885202

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

APO2 , CD261 , DR4 , TNF receptor superfamily member 10a , TNFRSF10A , TRAILR1 , TRAIL-R1

Cellular Localization

Membrane

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

Database

  • Gene ID: 8797 TNFRSF10A
  • UniProt: O00220 TNFRSF10A

Research Area

DATA IMAGES

Anti-DR4 antibody [DR-4-02] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00590

GTX00590 ICC/IF Image

ICC/IF analysis of HeLa transfected with TRAIL-R1 using GTX00590 DR4 antibody [DR-4-02].

REFERENCE

Application Reference

Yagolovich AV et al. Transl Oncol 2020; 13 (4) : 100762 Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399