*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Jurkat Cell Lysate(GTX27899) , HepG2 Cell Lysate(GTX27900) , Human Spleen Tissue Slide
Does not cross react with DR5.
PBS with 0.02% sodium azide.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1mg/ml(Please refer to the vial label for the specific concentration.)
Synthetic peptide, corresponding to amino acids 427-445 of Human DR4.
Purified by antigen-affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Tnf Receptor Superfamily Member 10A,Apo2,Cd261,Dr4,Trailr-1,Trailr1,Tnfrsf10A
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1and Fas. A novel cell death receptor was recently identified and designated DR4 (for death receptor4)(1). The ligand for this novel death receptor has been identified and termed TRAIL (2,3), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1)(4). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4mediates apoptosis and NF-kB activation in many tissues and cells.