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DR5 antibody [DR5-01-1]

Cat. No. GTX80178

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 DR5-01-1

Isotype

 IgG1

Application

 FACS

Reactivity

 Human
Package
100 μg ($339)
See all DR5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Not tested in other applications.

Calculated MW

48 kDa. ( Note )

Product Note

This antibody recognizes an extracellular domain of TRAIL-R2 (DR5).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.

Purification

Protein A purified

Conjugation

Unconjugated

RRID

AB_11178449

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD262 , DR5 , KILLER , KILLER/DR5 , TNF receptor superfamily member 10b , TNFRSF10B , TRAILR2 , TRICK2 , TRICK2A , TRICK2B , TRICKB , ZTNFR9 , TRAIL-R2

Cellular Localization

Membrane

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Database

  • Gene ID: 8795 TNFRSF10B
  • UniProt: O14763 TNFRSF10B

Research Area

REFERENCE

Application Reference

?rtykov ?? et al. Cancers (Basel) 2020; 12 (5) Chemotherapeutic Agents Sensitize Resistant Cancer Cells to the DR5-Specific Variant DR5-B more Efficiently than to TRAIL by Modulating the Surface Expression of Death and Decoy Receptors.
Application : FACS
Yagolovich AV et al. Transl Oncol 2020; 13 (4) : 100762 Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339