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DR5 antibody [HS201] (Azide free)

Cat. No. GTX33945

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 HS201

Isotype

 IgG1

Application

 ICC/IF, FACS, IP, Neutralizing/Inhibition

Reactivity

 Human
Package
100 μg ($499)
See all DR5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
FACS Assay dependent
IP Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

Neutralizing/Inhibition
Blocks TRAIL-R2 mediated killing if applied in solution)
Not tested in other applications.

Calculated MW

48 kDa. ( Note )

Product Note

Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.

PROPERTIES

Form

Liquid

Buffer

PBS, 10% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human TRAIL-R2 (DR5).

Purification

Protein G-affinity purified.

Purity

??95% by SDS-PAGE.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TNF receptor superfamily member 10b , CD262 , DR5 , KILLER , KILLER/DR5 , TRAIL-R2 , TRAILR2 , TRICK2 , TRICK2A , TRICK2B , TRICKB , ZTNFR9

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Database

  • Gene ID: 8795 TNFRSF10B
  • UniProt: O14763 TNFRSF10B

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Package List Price ($)
$ 499