GeneTex
United States (US)

DR5 antibody [HS201] (Azide free)

Cat No. GTX33945

Host Mouse
Clonality Monoclonal
Clone Name HS201
Isotype IgG1
Application ICC/IF, FACS, IP, Functional Assay
Reactivity Human
APPLICATION

Application Note

Functional Assay: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution).

Calculated MW

48 kDa. ( Note )

Specificity/Sensitivity

Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.
PROPERTIES

Form

Liquid

Buffer

PBS containing 10% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human TRAIL-R2 (DR5).

Purification

Protein G-affinity purified.

Purity

≧95% (SDS-PAGE)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tnf Receptor Superfamily Member 10B,Cd262,Dr5,Killer,Killer/Dr5,Trail-R2,Trailr2,Trick2,Trick2A,Trick2B,Trickb,Ztnfr9,Tnfrsf10B

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Database

Research Area

Package List Price ($)
$ 429