Functional Assay: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution).
Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.
PBS containing 10% glycerol.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1 mg/ml (Please refer to the vial label for the specific concentration.)
Recombinant human TRAIL-R2 (DR5).
Protein G-affinity purified.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Tnf Receptor Superfamily Member 10B,Cd262,Dr5,Killer,Killer/Dr5,Trail-R2,Trailr2,Trick2,Trick2A,Trick2B,Trickb,Ztnfr9,Tnfrsf10B
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]