DR5 antibody

Cat. No. GTX21675

Host	Goat
Clonality	Polyclonal
Isotype	IgG
Application	WB, FACS, ELISA, IHC
Reactivity	Human, Mouse
Package	100 μg ($399)

See all DR5 products

Datasheet

View product citations for antibody GTX21675 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:500
FACS	2μl/10⁶ cells/100μl
ELISA	1:75,000
IHC	1:300

Not tested in other applications.

Calculated MW

48 kDa. ( Note )

Product Note

<0.2% cross-reactivity to TRAIL R3 peptide of the same region. Not likely to bind TRAIL R1 due to low sequence homology in this region.

PROPERTIES

Form

Liquid

Buffer

10mM KHPO₄, 140mM NaCl, 0.1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide 68APQQKRSSPSEGLCPPGHHISEDGRDC94 of the extracellular domain of human TRAIL-R2 (DR5)

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD262,DR5,KILLER,KILLER/DR5,TNF receptor superfamily member 10b,TNFRSF10B,TRAILR2,TRICK2,TRICK2A,TRICK2B,TRICKB,ZTNFR9,TRAIL-R2

Cellular Localization

Membrane

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Database

Gene ID: 8795 TNFRSF10B
UniProt: O14763 TNFRSF10B

Research Area

DATA IMAGES

GTX21675 IHC Image

IHC analysis of human spleen tissue using GTX21675 DR5 antibody.

REFERENCE

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REVIEW

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Package

List Price ($)

100 μg

$ 399

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