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United States (US)

DR5 antibody

Cat. No. GTX70465

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ELISA

Reactivity

 Human
Package
100 μl ($399)
See all DR5 products

APPLICATION

Application Note

Not tested. The investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Calculated MW

48 kDa. ( Note )

Product Note

Reacts with the N terminus of the human TRAIL-R2 protein.

PROPERTIES

Form

Liquid

Buffer

Serum

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Purification

Serum

Conjugation

Unconjugated

RRID

AB_374154

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TNF receptor superfamily member 10b , CD262 , DR5 , KILLER , KILLER/DR5 , TRAIL-R2 , TRAILR2 , TRICK2 , TRICK2A , TRICK2B , TRICKB , ZTNFR9

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Database

  • Gene ID: 8795 TNFRSF10B
  • UniProt: O14763 TNFRSF10B

Research Area

REFERENCE

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399