GeneTex
United States (US)

DR6 antibody [DR-6-04-EC]

DR6-antibody-DR-6-04-EC__GTX14740-2_18121410_842.jpg
DR6-antibody-DR-6-04-EC__GTX14740-1_18121410_766.jpg

Cat No. GTX14740

Host Mouse
Clonality Monoclonal
Clone Name DR-6-04-EC
Isotype IgG1
Application ICC/IF, FACS, IP
Reactivity Human
APPLICATION

Application Note

FACS: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Antibody immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

72 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Phosphate buffered saline pH 7.4 containing 15mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Fusion protein, corresponding to extracellular amino acids 42-335 of Human DR6, linked to the Fc portion of human IgG1.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tnf Receptor Superfamily Member 21,Bm-018,Cd358,Dr6,Tnfrsf21

Cellular Localization

Cell Membrane

Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNFR1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines. The ligand for DR6 hasnot been identified.

Database

Research Area

DATA IMAGES
DR6-antibody-DR-6-04-EC__GTX14740-2_18121410_842.jpg

GTX14740 FACS Image

Flow cytometry analysis of cell surface expression of DR6 in 6 different cell lines using purified anti-DR6 antibody (GTX14740). Detection by Goat anti-mouse IgG1: PE.

DR6-antibody-DR-6-04-EC__GTX14740-1_18121410_766.jpg

GTX14740 ICC/IF Image

Detection of DR6 transiently transfected into HeLa cells (green) using anti-DR6 antibody (GTX14740). Cell nuclei visualized by DAPI (blue).

Package List Price ($)
$ 319