GeneTex
United States (US)

DR6 antibody

DR6-antibody_WB_GTX28417-1_18121410_893.jpg

Cat No. GTX28417

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

Western blot at 1:500 to 1:2000 dilution.

Calculated MW

72 kDa. ( Note )

Positive Control

HeLa andK562 whole cell lysateAn approximately 68 kDa band can be detected.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to amino acids 42-56 of Human DR6.

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tnf Receptor Superfamily Member 21,Bm-018,Cd358,Dr6,Tnfrsf21

Cellular Localization

Cell Membrane

Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6 (1). Like TNF-R1, DR6interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed inhuman tissues and cell lines (1). The ligand for DR6 has not been identified.

Database

Research Area

DATA IMAGES
DR6-antibody_WB_GTX28417-1_18121410_893.jpg

GTX28417 WB Image

Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide with anti-DR6 (NT) (GTX28417) at 2ug/ml.

Package List Price ($)
$ 329