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DUOX1 antibody, Internal

Anti-DUOX1 antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX88773

Cat. No. GTX88773

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all DUOX1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 4-6μg/ml

Note :

IHC-P
Human Thyroid shows staining of membranes in epithelial cells of the gland.
Not tested in other applications.

Calculated MW

177 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88773-PEP).

Product Note

This antibody is expected to recognise both reported isoforms (NP_059130.2 ; NP_787954.1) which are identical.

PROPERTIES

Form

Liquid

Buffer

TBS, 0.5% BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence EKFQRSCLHQTVQ, from the internal region of the protein sequence according to NP_059130.2 ; NP_787954.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

dual oxidase 1 , LNOX1 , NOXEF1 , THOX1

Cellular Localization

Apical cell membrane

Background

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

Database

Research Area

DATA IMAGES

Anti-DUOX1 antibody, Internal used in IHC (Paraffin sections) (IHC-P). GTX88773

GTX88773 IHC-P Image

IHC-P analysis of human thyroid Gland using GTX88773 DUOX1 antibody, Internal.
Antigen retrieval : Tris/EDTA buffer pH 9
Dilution : 4μg/ml

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399