APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:2000 |
| 1:50-1:100 |
Not tested in other applications.
Calculated MW
Predict Reactivity
Rat, Xenopus(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A.
Purification
Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
dual specificity tyrosine phosphorylation regulated kinase 1A , DYRK , DYRK1 , HP86 , MNB , MNBH , MRD7
Cellular Localization
Nucleus,Nucleus speckle
Background
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX81398 IHC-P Image
IHC-P analysis of human prostate carcinoma using GTX81398 DYRK1A antibody, N-term.
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GTX81398 WB Image
WB analysis of various samples using GTX81398 DYRK1A antibody, N-term.
Lane 1: mouse brain lysates
Lane 2: HeLa whole cell lysates
Loading : 20 μg per lane
Dilution : 1:2000
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REFERENCE
There are currently no references for DYRK1A antibody, N-term (GTX81398). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for DYRK1A antibody, N-term (GTX81398). Be the first to share your experience with this product.
