GeneTex
United States (US)

DYRK1A antibody

GTX31433_2629_WB_20180221_18121410_966.jpg
GTX31433_167_ICC-IF_20180221_18121410_138.jpg
GTX31433_2628_WB_20180221_18121410_536.jpg

Cat No. GTX31433

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 - 2 μg/mL
ICC/IF 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

86 kDa. ( Note )

Positive Control

HeLa Cell Slide(GTX25529) , K562 Cell Lysate(GTX27911) , HeLa Cell Lysate

Specificity/Sensitivity

Multiple isoforms of DYRK1A are known to exist. DYRK1A antibody will not cross-react with other DYRK family members
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

DYRK1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human DYRK1A.The immunogen is located within the last 50 amino acids of DYRK1A.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A,Dyrk,Dyrk1,Hp86,Mnb,Mnbh,Mrd7,Dyrk1A

Background

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX31433_2629_WB_20180221_18121410_966.jpg

GTX31433 WB Image

WB analysis of K562 cell lysate using GTX31433 DYRK1A antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

GTX31433_167_ICC-IF_20180221_18121410_138.jpg

GTX31433 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX31433 DYRK1A antibody.
Working concentration : 10 μg/ml

GTX31433_2628_WB_20180221_18121410_536.jpg

GTX31433 WB Image

WB analysis of HeLa cell lysate using GTX31433 DYRK1A antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Package List Price ($)
$ 329