APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 - 2 μg/mL |
| 10 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
HeLa Cell Slide(GTX25529) , K562 Cell Lysate(GTX27911) , HeLa Cell Lysate
Product Note
Multiple isoforms of DYRK1A are known to exist. DYRK1A antibody will not cross-react with other DYRK family members
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
DYRK1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human DYRK1A.The immunogen is located within the last 50 amino acids of DYRK1A.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
dual specificity tyrosine phosphorylation regulated kinase 1A , DYRK , DYRK1 , HP86 , MNB , MNBH , MRD7
Cellular Localization
Nucleus,Nucleus speckle
Background
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
|
GTX31433 ICC/IF Image
ICC/IF analysis of HeLa cells using GTX31433 DYRK1A antibody.
Working concentration : 10 μg/ml
|
|
|
GTX31433 WB Image
WB analysis of K562 cell lysate using GTX31433 DYRK1A antibody.
Working concentration : (A) 1 and (B) 2 μg/ml
|
|
|
GTX31433 WB Image
WB analysis of HeLa cell lysate using GTX31433 DYRK1A antibody.
Working concentration : (A) 1 and (B) 2 μg/ml
|
REFERENCE
There are currently no references for DYRK1A antibody (GTX31433). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for DYRK1A antibody (GTX31433). Be the first to share your experience with this product.
