Daxx antibody [N1N3]

Name: Daxx antibody [N1N3]
Brand: GeneTex
SKU: GTX112908
Price: 399.00 USD
Rating: 5 (1 reviews)

Anti-Daxx antibody [N1N3] used in IHC (Paraffin sections) (IHC-P). GTX112908

Anti-Daxx antibody [N1N3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX112908

Anti-Daxx antibody [N1N3] used in Western Blot (WB). GTX112908

Cat. No. GTX112908

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-P
Reactivity	Human
Package	100 μl ($399), 25 μl ($169)

See all Daxx products

Datasheet
Document

View product citations for antibody GTX112908 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:500-1:3000
ICC/IF	1:100-1:1000
IHC-P	1:100-1:1000

Not tested in other applications.

Calculated MW

81 kDa. ( Note )

Positive Control

A431 , H1299 , Raji

Predict Reactivity

Mouse, Rat, Bovine(>80% identity)

PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.63 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human Daxx. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1950091

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

death domain associated protein , BING2 , DAP6 , EAP1 , SMIM40

Cellular Localization

Nucleus , Cytoplasm

Background

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Database

Gene ID: 1616 DAXX
UniProt: Q9UER7 DAXX

Research Area

DATA IMAGES

GTX112908 IHC-P Image

Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using Daxx(GTX112908) antibody at 1:500 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

GTX112908 ICC/IF Image

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Daxx(GTX112908) antibody at 1:200 dilution.

GTX112908 WB Image

Sample (30 ug of whole cell lysate)
A: A431
B: H1299
C: Raji
7.5% SDS PAGE
GTX112908 diluted at 1:1000

REFERENCE

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REVIEW