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DcR1 antibody [TRAIL-R3-02] (APC)

Cat. No. GTX00615-07

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 TRAIL-R3-02

Isotype

 IgG1

Application

 FACS

Reactivity

 Human
Package
100 μg ($369)
See all DcR1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Not tested in other applications.

Calculated MW

27 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

TRAIL-R3 (aa 1-280) - hIgGhc fusion protein

Purification

Purified by size-exclusion chromatography

Conjugation

Allophycocyanin (APC)

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD263 , DCR1 , DCR1TNFR , LIT , TNF receptor superfamily member 10c , TNFRSF10C , TRAILR3 , TRID , DcR1 , TRAIL-R3

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

Database

  • Gene ID: 8794 TNFRSF10C
  • UniProt: O14798 TNFRSF10C

Research Area

REFERENCE

Clone Reference

Zhang M et al. PLoS One 2015; 10 (5):e0127386 The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 369