GeneTex
United States (US)

DcR3 antibody

DcR3-antibody_IHC-P_GTX28405-1_18121409_101.jpg
DcR3-antibody_WB_GTX28405-1_18121409_495.jpg

Cat No. GTX28405

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

Western blot at 1:500 to 1:1000 dilution.

Calculated MW

33 kDa. ( Note )

Positive Control

Tissue lysate of human heart An approximately 33 kDa band can be detected.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide corresponding to amino acids 31 to 46 ofhuman DcR3 precursor (1,2).

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

M68, O95407, TR6, DJ583P15.1.1, 8771, TNFRSF6B, DCR3, 603361

Cellular Localization

Secreted

Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to complete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively, (1,2). Unlike DcR1and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis (1,2). DcR3transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.

Database

Research Area

DATA IMAGES
DcR3-antibody_IHC-P_GTX28405-1_18121409_101.jpg

GTX28405 IHC-P Image

Immunohistochemical staining of DcR3 in human heart tissue with DcR3 antibody (GTX28405) at 1μg/ml.

DcR3-antibody_WB_GTX28405-1_18121409_495.jpg

GTX28405 WB Image

Western blot analysis of DcR3 in human heart (H), brain (B), and kidney (K) tissue lysates with DcR3 antibody (GTX28405) at 1μg/ml.

Package List Price ($)
$ 329