Western blot at 1:500 to 1:1000 dilution.
Tissue lysate of human heart An approximately 33 kDa band can be detected.
PBS with 0.02% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.5mg/ml(Please refer to the vial label for the specific concentration.)
Peptide corresponding to amino acids 31 to 46 ofhuman DcR3 precursor (1,2).
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
M68, O95407, TR6, DJ583P15.1.1, 8771, TNFRSF6B, DCR3, 603361
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to complete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively, (1,2). Unlike DcR1and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis (1,2). DcR3transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.
GTX28405 IHC-P Image
Immunohistochemical staining of DcR3 in human heart tissue with DcR3 antibody (GTX28405) at 1μg/ml.
GTX28405 WB Image
Western blot analysis of DcR3 in human heart (H), brain (B), and kidney (K) tissue lysates with DcR3 antibody (GTX28405) at 1μg/ml.