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Desmoglein 1 antibody [DSG1/1733]

Anti-Desmoglein 1 antibody [DSG1/1733] used in IHC (Paraffin sections) (IHC-P). GTX34675

Cat. No. GTX34675

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 DSG1/1733

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($529)
See all Desmoglein 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1-2μg/ml for 30 minutes at RT

Note :

IHC-P
Staining of formalin-fixed tissues require heating tissue sections in 10mM Tris buffer with 1mM EDTA, pH 8.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

114 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human desmoglein-1 protein fragment corresponding to intracellular domain

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CDHF4 , DG1 , DSG , DSG1 , EPKHE , EPKHIA , PPKS1 , SPPK1 , desmoglein 1 , Desmoglein 1

Cellular Localization

Cell membrane,Cell junction,Desmosome

Background

This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]

Database

Research Area

DATA IMAGES

Anti-Desmoglein 1 antibody [DSG1/1733] used in IHC (Paraffin sections) (IHC-P). GTX34675

GTX34675 IHC-P Image

IHC-P analysis of human skin tissue using GTX34675 Desmoglein 1 antibody [DSG1/1733].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529