*Optimal dilutions/concentrations should be determined by the researcher.
Human Heart shows staining of the junctons between cardiomuscular fibres.
Not tested in other applications.
The peptide used to generate this antibody is available for purchase (GTX88029-PEP).
This antibody is expected to recognize reported isoform I (NP_004406.2) only.
Mouse, Rat(>80% identity)
Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.
Peptide with sequence C-QESVKQAHLRNEH, from the internal region of the protein sequence according to NP_004406.2.
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
DPII Antibody , DP Antibody , DSP Antibody , DPI Antibody
Innermost portion of the desmosomal plaque.
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
GTX88029 IHC-P Image
IHC-P analysis of human heart using GTX88029 Desmoplakin (aa 1672 -1684) antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 3.8µg/ml