GeneTex
United States (US)

Desmoplakin (aa 1672 -1684) antibody, Internal

GTX88029_1065_IHC-P_18122102_858.jpg

Cat No. GTX88029

Host Goat
Clonality Polyclonal
Isotype IgG
Application IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 3-6μg/ml

Note :

Human Heart shows staining of the junctons between cardiomuscular fibres.
Not tested in other applications.

Calculated MW

332 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88029-PEP).

Specificity/Sensitivity

This antibody is expected to recognize reported isoform I (NP_004406.2) only.

Predict Reactivity

Mouse, Rat(>80% identity)
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Concentration

0.50mg/ml

Antigen Species

Human

Immunogen

Peptide with sequence C-QESVKQAHLRNEH, from the internal region of the protein sequence according to NP_004406.2.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

DPII Antibody , DP Antibody , DSP Antibody , DPI Antibody

Cellular Localization

Innermost portion of the desmosomal plaque.

Background

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
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Database

DATA IMAGES
GTX88029_1065_IHC-P_18122102_858.jpg

GTX88029 IHC-P Image

IHC-P analysis of human heart using GTX88029 Desmoplakin (aa 1672 -1684) antibody, Internal.
Antigen retrieval : citrate buffer pH 6
Dilution : 3.8µg/ml

Package List Price ($)
$ 329