GeneTex
United States (US)

Desmoplakin antibody

GTX32557_20180530_WB_18121410_208.jpg
GTX32557_20180530_IHC-P_18121410_321.jpg

Cat No. GTX32557

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

332 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DSP (NP_004406.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Desmoplakin,Dcwhkta,Dp,Dsp

Background

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]

Database

DATA IMAGES
GTX32557_20180530_WB_18121410_208.jpg

GTX32557 WB Image

WB analysis of various samples using GTX32557 Desmoplakin antibody.
Dilution : 1:1000
Loading : 25μg per lane

GTX32557_20180530_IHC-P_18121410_321.jpg

GTX32557 IHC-P Image

IHC-P analysis of human liver injury tissue using GTX32557 Desmoplakin antibody.
Dilution : 1:100

REFERENCE
Package List Price ($)
$ 329