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Doublecortin antibody [JJ0959]

Recombinant antibody
Anti-Doublecortin antibody [JJ0959] used in Western Blot (WB). GTX01006
Anti-Doublecortin antibody [JJ0959] used in Flow cytometry (FACS). GTX01006

Cat No. GTX01006

Host

Rabbit

Clonality

Monoclonal

Clone Name

JJ0959

Isotype

IgG

Application

WB, FACS

Reactivity

Human
Package
100 μl ($369)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:1000-1:5000
FACS 1:50-1:100
Not tested in other applications.

Calculated MW

49 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

1x TBS (pH7.4), 1% BSA, 40% glycerol, 0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

doublecortin,DBCN,DC,DCX,LISX,SCLH,XLIS,Doublecortin

Cellular Localization

Cytoplasm,Cell projection

Background

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Database

Research Area

DATA IMAGES

Anti-Doublecortin antibody [JJ0959] used in Western Blot (WB). GTX01006

GTX01006 WB Image

WB analysis of human brain tissue lysate using GTX01006 Doublecortin antibody [JJ0959].
Dilution : 1:1000

Anti-Doublecortin antibody [JJ0959] used in Flow cytometry (FACS). GTX01006

GTX01006 FACS Image

FACS analysis of HepG2 cells using GTX01006 Doublecortin antibody [JJ0959].
Red : primary antibody
Black : unlabelled control
Dilution : 1:50

REFERENCE

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REVIEW

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Package List Price ($)
$ 369