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Drebrin antibody

KO/KD Overexpression
Anti-Drebrin antibody used in Western Blot (WB). GTX11068
Anti-Drebrin antibody used in Western Blot (WB). GTX11068
Anti-Drebrin antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX11068
Anti-Drebrin antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX11068

Cat. No. GTX11068

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Rat
Package
50 μl ($399)
See all Drebrin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1,000
ICC/IF Assay dependent
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

71 kDa. ( Note )

Positive Control

HeLa, rat brain cytosol

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

synthetic peptide corresponding to the N-terminal region of human drebrin E/A (amino acids 22-42) conjugated to KLH.

Purification

IgG fraction

Conjugation

Unconjugated

RRID

AB_369916

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

drebrin 1 , D0S117E

Cellular Localization

Cytoplasm,Cell projection, dendrite,Cell junction

Background

The cortical cytoskeleton, a highly cross-linked submembranal F-actin filament network, plays an important role in cell proliferation, differentiation, migration, cell morphology and oncogenic transformation. Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the adult or A isoform (95-120 kDa). An additional truncated form of drebrin A, s-drebrin/A2 (42 kDa), is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites.

Database

Research Area

DATA IMAGES

Anti-Drebrin antibody used in Western Blot (WB). GTX11068

GTX11068 WB Image

KO/KD Overexpression

The data was published in the journal Oncogene in 2017. PMID: 28319065

Anti-Drebrin antibody used in Western Blot (WB). GTX11068

GTX11068 WB Image

The data was published in the journal Oncogene in 2017. PMID: 28319065

Anti-Drebrin antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX11068

GTX11068 ICC/IF Image

The data was published in the journal Oncogene in 2017. PMID: 28319065

Anti-Drebrin antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX11068

GTX11068 ICC/IF Image

The data was published in the journal Oncogene in 2017. PMID: 28319065

REFERENCE

Application Reference

Dart AE et al. Oncogene 2017; (Epub) The drebrin/EB3 pathway drives invasive activity in prostate cancer.
Application : IHC-P
Reactivity : Human
Submit a Reference

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399