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E-Cadherin antibody [21E9]

Anti-E-Cadherin antibody [21E9] used in IHC (Paraffin sections) (IHC-P). GTX52491

Cat No. GTX52491

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 21E9

Isotype

 IgG2

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($359)
See all E-Cadherin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:100 - 1:1000
IHC-P 1:200 - 1:400
Not tested in other applications.

Calculated MW

97 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human recombinant E-Cadherin protein

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Arc1 , CD324 , CDH1 , CDHE , ECAD , LCAM , UVO , cadherin 1 , E-Cadherin , Cadherin 1

Cellular Localization

Cell junction,Cell membrane,Endosome,Golgi apparatus,trans-Golgi network

Background

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

Database

Research Area

DATA IMAGES

Anti-E-Cadherin antibody [21E9] used in IHC (Paraffin sections) (IHC-P). GTX52491

GTX52491 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52491 E-Cadherin antibody [21E9].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 359