APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1/500 - 1/2000 |
1/200 - 1/1000 |
1/200 - 1/400 |
1/10000 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
Ascites
Preservative
0.03% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Antigen Species
Human
Immunogen
Purified recombinant fragment of human CDH1 expressed in E. Coli.
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
cadherin 1 , Arc-1 , BCDS1 , CD324 , CDHE , ECAD , LCAM , UVO
Cellular Localization
Cell junction,Cell membrane,Endosome
Background
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX82753 FACS Image
FACS analysis of HeLa cells using GTX82753 E-Cadherin antibody [7H12]. Green : E-Cadherin Purple : negative control
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GTX82753 IHC-P Image
IHC-P analysis of gastric cancer tissue (left) and lung cancer tissue (right) using GTX82753 E-Cadherin antibody [7H12].
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GTX82753 WB Image
WB analysis of LNCAP (1),A431 (2), DU145 (3), PC-3 (4), MCF-7 (5), PC-12 (6), NIH3T3 (7), C6 (8) and COS7 (9) cell lysate using GTX82753 E-Cadherin antibody [7H12].
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REFERENCE
There are currently no references for E-Cadherin antibody [7H12] (GTX82753). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for E-Cadherin antibody [7H12] (GTX82753). Be the first to share your experience with this product.