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E2F4 antibody [WUF11]

Cat No. GTX11951

Host

Mouse

Clonality

Monoclonal

Clone Name

WUF11

Isotype

IgG1

Application

WB

Reactivity

Human
Package
50 μl ($299)

APPLICATION

Application Note

WB: Use at a dilution of 1/500 - 1/1000. Detects a band of approximately 60 kDa. Uncharacterized bands of lower and higher molecular weight may also be revealed under similar conditions. For optimal results primary antibody incubations should be performed at 37ºC Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

44 kDa. ( Note )

Positive Control

K-562 nuclear extract

PROPERTIES

Form

Liquid

Buffer

Preservative: 0.2% Gelatin, 0.01% Thimerosal and 0.1% Sodium Azide; Constituents: PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Full-length protein corresponding to human E2F-4.

Purification

Tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

E2F transcription factor 4 , E2F-4

Cellular Localization

Nucleus

Background

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

There are currently no references for E2F4 antibody [WUF11] (GTX11951). Be the first to share your publications with this product.

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Thimerosal.pdf
Package List Price ($)
$ 299