Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Immunogen Sequence: GI # 24041020, sequence 41-168 Recombinant embryonic ectoderm development isoform a
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
RRID
AB_370265
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
embryonic ectoderm development , COGIS , HEED , WAIT1
Cellular Localization
Nucleus
Background
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Four transcript variants encoding distinct isoforms have been identified for this gene. The four isoforms are differentialy expressed during ES cell differentiation, with four isoforms intially expressed. Only isoform 3 then remains after differentiation.
Database
Research Area