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EPO receptor antibody [MM0031-6G7]

Anti-EPO receptor antibody [MM0031-6G7] used in IHC (Paraffin sections) (IHC-P). GTX52483

Cat. No. GTX52483

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MM0031-6G7

Isotype

 IgG2

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all EPO receptor products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000 - 1:2000
IHC-P 1:50 - 1:300
Not tested in other applications.

Calculated MW

55 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human rEPO receptor (extracellular domain)

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

EPOR , erythropoietin receptor , EPO receptor

Cellular Localization

Cell membrane,Secreted

Background

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Database

Research Area

DATA IMAGES

Anti-EPO receptor antibody [MM0031-6G7] used in IHC (Paraffin sections) (IHC-P). GTX52483

GTX52483 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52483 EPO receptor antibody [MM0031-6G7]. Proteinase K pretreatment is required.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399