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EPO receptor antibody

Anti-EPO receptor antibody used in IHC (Frozen sections) (IHC-Fr). GTX37704
Anti-EPO receptor antibody used in IHC (Paraffin sections) (IHC-P). GTX37704
Anti-EPO receptor antibody used in IHC (Paraffin sections) (IHC-P). GTX37704
Anti-EPO receptor antibody used in Western Blot (WB). GTX37704

Cat. No. GTX37704

Reference 3

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, IHC-Fr

Reactivity

 Human, Rat
Package
100 μg ($459)
See all EPO receptor products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:200-1000
IHC-P 1:100-500
IHC-Fr Assay dependent
Not tested in other applications.

Calculated MW

55 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human EPOR.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

erythropoietin receptor , EPO-R

Cellular Localization

Cell membrane; Single-pass type I membrane protein

Background

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Database

Research Area

DATA IMAGES

Anti-EPO receptor antibody used in IHC (Frozen sections) (IHC-Fr). GTX37704

GTX37704 IHC-Fr Image

IHC-Fr analysis of human lung cancer tissue using GTX37704 EPO receptor antibody.
Dilution : 2.5μg/ml

Anti-EPO receptor antibody used in IHC (Paraffin sections) (IHC-P). GTX37704

GTX37704 IHC-P Image

IHC-P analysis of human lung cancer tissue using GTX37704 EPO receptor antibody.
Dilution : 2.5μg/ml

Anti-EPO receptor antibody used in IHC (Paraffin sections) (IHC-P). GTX37704

GTX37704 IHC-P Image

IHC-P analysis of human lung cancer tissue using GTX37704 EPO receptor antibody.
Dilution : 2.5μg/ml

Anti-EPO receptor antibody used in Western Blot (WB). GTX37704

GTX37704 WB Image

WB analysis of rat thyroid (Lane 1), human thyroid cancer (Lane 2), human breast cancer (Lane 3), human lung cancer (Lane 4), U251 cell (Lane 5) lysates using GTX37704 EPO receptor antibody.
Dilution : 1μg/ml

REFERENCE

Application Reference

D He et al. Neurosci Bull 2024; Microglial EPOR Contribute to Sevoflurane-induced Developmental Fine Motor Deficits Through Synaptic Pruning in Mice
Application : WB
Rey F et al. Antioxidants (Basel) 2021; 10 (1) Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinson's Disease.
Application : WB
Reactivity : Human
Arellano-Buend?a AS et al. Antioxidants (Basel) 2020; 9 (11) Effects of Allicin on Pathophysiological Mechanisms during the Progression of Nephropathy Associated to Diabetes.
Application : WB
Reactivity : Rat
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 459