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ER81 antibody

Anti-ER81 antibody used in IHC (Paraffin sections) (IHC-P). GTX02562
Anti-ER81 antibody used in Western Blot (WB). GTX02562
Anti-ER81 antibody used in Western Blot (WB). GTX02562

Cat. No. GTX02562

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human
Package
100 μl ($419)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

55 kDa. ( Note )

Predict Reactivity

Mouse, Rat, Zebrafish, Rabbit, Bovine, Dog, Guinea pig, Horse(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 2% Sucrose

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 - 1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human ETV1.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ETS variant 1 , ER81

Cellular Localization

Nucleus

Background

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]

Database

Research Area

DATA IMAGES

Anti-ER81 antibody used in IHC (Paraffin sections) (IHC-P). GTX02562

GTX02562 IHC-P Image

IHC-P analysis of human cortex tissue using GTX02562 ER81 antibody.
Dilution : 5 μg/ml

Anti-ER81 antibody used in Western Blot (WB). GTX02562

GTX02562 WB Image

WB analysis of MDA-MB-435s cell lysate using GTX02562 ER81 antibody.
Dilution : 1 μg/ml

Anti-ER81 antibody used in Western Blot (WB). GTX02562

GTX02562 WB Image

WB analysis of ER81-transfected HEK293 cell lysate using GTX02562 ER81 antibody.
Lane 1 : 100 μg untransfected HEK293 lysate
Lane 2 : 33 μg ER81 transfected HEK293 lysate
Dilution : 1:1000

REFERENCE

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REVIEW

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Package List Price ($)
$ 419