GeneTex

  • Country / Location Selection

United States (US)

ERK1/2 antibody

Cat. No. GTX16573

Host

 Sheep

Clonality

 Polyclonal

Isotype

 IgG

Application

 IP

Reactivity

 Human, Rat
Package
125 μg ($399)
See all ERK1/2 products

APPLICATION

Application Note

IP: Use at a concentration of 1 - 10 μg/ml. Optimal dilutions/concentrations should be determined by the end user.

Positive Control

HeLa cell lysate

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Cellular Localization

Cell Membrane

Background

ERK (extracellular signal regulated kinase), also known as MAPK (mitogen-activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.

Research Area

REFERENCE

There are currently no references for ERK1/2 antibody (GTX16573). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for ERK1/2 antibody (GTX16573). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399