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ERR gamma antibody

Anti-ERR gamma antibody used in IHC (Paraffin sections) (IHC-P). GTX71313
Anti-ERR gamma antibody used in IHC (Paraffin sections) (IHC-P). GTX71313
Anti-ERR gamma antibody used in IHC (Paraffin sections) (IHC-P). GTX71313

Cat No. GTX71313

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

IHC-P

Reactivity

Human, Mouse, Rat, Zebrafish, Rabbit, Bovine, Dog, Hamster, Chicken, Monkey, Bat, Horse, Xenopus
Package
25 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 34 - 68 μg/ml
Not tested in other applications.

Calculated MW

51 kDa. ( Note )

Predict Reactivity

Japanese Medaka, Elephant, Gibbon, Gorilla, Lizard, Marmoset, Opossum, Orangutan, Panda, Pufferfish, Turkey, Platypus, Stickleback(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic 16 amino acid peptide near N-terminus of human ESRRG / ERR3.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

estrogen related receptor gamma , ERR3 , ERRgamma , ESRRG , NR3B3 , ERR gamma , Estrogen Related Receptor gamma

Cellular Localization

Nucleus

Background

This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]

Database

Research Area

DATA IMAGES

Anti-ERR gamma antibody used in IHC (Paraffin sections) (IHC-P). GTX71313

GTX71313 IHC-P Image

IHC-P analysis of human breast cancer tissue using GTX71313 ERR gamma antibody.
Antigen retrieval : Heat-induced antigen retrieval

Anti-ERR gamma antibody used in IHC (Paraffin sections) (IHC-P). GTX71313

GTX71313 IHC-P Image

IHC-P analysis of human kidney tissue using GTX71313 ERR gamma antibody.
Antigen retrieval : Heat-induced antigen retrieval

Anti-ERR gamma antibody used in IHC (Paraffin sections) (IHC-P). GTX71313

GTX71313 IHC-P Image

IHC-P analysis of human kidney, diabetes tissue using GTX71313 ERR gamma antibody.
Antigen retrieval : Heat-induced antigen retrieval

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf