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ESX1 antibody

Anti-ESX1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85009
Anti-ESX1 antibody used in Western Blot (WB). GTX85009
Anti-ESX1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85009

Cat. No. GTX85009

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human
Package
100 μg ($399)
See all ESX1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

44 kDa. ( Note )

Positive Control

Human Testis Tissue Lysate(GTX15374) , Human Testis Tissue Slide(GTX21748)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

ESX1 antibody was raised against a 19 amino acid synthetic peptide near the center of human ESX1.The immunogen is located within amino acids 140 - 190 of ESX1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ESX homeobox 1 , ESX1L , ESXR1

Cellular Localization

Cytoplasm,Nucleus

Background

Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.

Database

DATA IMAGES

Anti-ESX1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85009

GTX85009 IHC-P Image

IHC-P analysis of human testis tissue using GTX85009 ESX1 antibody.
Working concentration : 20 μg/ml

Anti-ESX1 antibody used in Western Blot (WB). GTX85009

GTX85009 WB Image

WB analysis of human testis tissue lysate using GTX85009 ESX1 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-ESX1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85009

GTX85009 IHC-P Image

IHC-P analysis of human testis tissue using GTX85009 ESX1 antibody.
Working concentration : 2.5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399