*Optimal dilutions/concentrations should be determined by the researcher.
|1 - 5 μg/ml
Not tested in other applications.
MCF-7 , DDDDK-tagged ESR1-transfected 293T
This antibody is specific for ER alpha protein, and it does not cross react with ER beta protein.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1.56 mg/ml (Please refer to the vial label for the specific concentration.)
The region encoding amino acids 1-190 expressed in E. coli.
Protein G purified
From tissue culture supernatant
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
estrogen receptor 1 , ER , ESR , ESRA , ESTRR , Era , NR3A1
Cytoplasm , Cell membrane , Cell membrane; Single-pass type I membrane protein , Golgi apparatus
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]