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Estrogen Receptor alpha (phospho Ser106) antibody

Anti-Estrogen Receptor alpha (phospho Ser106) antibody used in IHC (Paraffin sections) (IHC-P). GTX32390
Anti-Estrogen Receptor alpha (phospho Ser106) antibody used in Western Blot (WB). GTX32390
Anti-Estrogen Receptor alpha (phospho Ser106) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX32390

Cat No. GTX32390

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-P

Reactivity

Human
Package
100 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
ICC/IF 1:100 - 1:500
IHC-P 1:100 - 1:200
Not tested in other applications.

Calculated MW

66 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.42% Potassium phosphate, 0.87% Sodium chloride pH 7.3, 30% glycerol, 0.01% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of Estrogen Receptor alpha. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

estrogen receptor 1 , ER , ESR , ESRA , ESTRR , Era , NR3A1

Cellular Localization

Cytoplasm,Cell membrane,Cell membrane; Single-pass type I membrane protein,Golgi apparatus

Background

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

Database

Research Area

DATA IMAGES

Anti-Estrogen Receptor alpha (phospho Ser106) antibody used in IHC (Paraffin sections) (IHC-P). GTX32390

GTX32390 IHC-P Image

IHC-P analysis of formalin fixed human breast cancer tissue section using GTX32390 Estrogen Receptor alpha (phospho Ser106) antibody.
Antigen retrieval : Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0)

Anti-Estrogen Receptor alpha (phospho Ser106) antibody used in Western Blot (WB). GTX32390

GTX32390 WB Image

WB analysis of EGF-treated MCF7 (A) whole cell lysates using GTX32390 Estrogen Receptor alpha (phospho Ser106) antibody.

Anti-Estrogen Receptor alpha (phospho Ser106) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX32390

GTX32390 ICC/IF Image

ICC/IF analysis of formalin-fixed MCF7 cells using GTX32390 Estrogen Receptor alpha (phospho Ser106) antibody.
Red : Primary antibody
Blue : DAPI
Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes

REFERENCE

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REVIEW

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Package List Price ($)
$ 319