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FADD antibody [FD19]

Cat No. GTX10519

Host Mouse
Clonality Monoclonal
Clone Name FD19
Isotype IgG1
Application WB, IP, ELISA
Reactivity Human
Package
100 μl ($339)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5-1 μg/ml
IP Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

23 kDa. ( Note )

Positive Control

A431
PROPERTIES

Form

Liquid

Buffer

0.01M PBS pH7.4, 15 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

~2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

purified recombinant human FADD.

Purification

Purified immunoglobulin

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Fas associated via death domain , GIG3 , MORT1

Background

FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C-terminal death domain that interacts with the Fas receptor death domain. The N-terminus contains a death effectors domain (DED, which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL-induced transcriptional activation of c-fos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK-293 cell line.

Database

Research Area

REFERENCE
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REVIEW
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Package List Price ($)
$ 339