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FANCD2 antibody [FI-17]

Orthogonal
Anti-FANCD2 antibody [FI-17] used in Western Blot (WB). GTX25360
Anti-FANCD2 antibody [FI-17] used in Western Blot (WB). GTX25360
Anti-FANCD2 antibody [FI-17] used in Western Blot (WB). GTX25360

Cat. No. GTX25360

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 FI-17

Isotype

 IgG1

Application

 WB, IP, ChIP assay

Reactivity

 Human
Package
100 μl ($429)
See all FANCD2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000 - 1:2000
IP Assay dependent
ChIP assay 1:10 - 1:500
Not tested in other applications.

Calculated MW

164 kDa. ( Note )

Product Note

We do not recommend use of this product for Mouse,Hamster samples.

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Human FANCD2 fusion protein [Swiss-Prot# Q9BXW9]

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

FA complementation group D2 , FA-D2 , FA4 , FACD , FAD , FAD2 , FANCD

Cellular Localization

Nucleus

Background

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-FANCD2 antibody [FI-17] used in Western Blot (WB). GTX25360

GTX25360 WB Image

Orthogonal

WB analysis of multiple cells treated with 10-Gy IR using GTX25360 FANCD2 antibody [FI-17].
Dilution : 1:1000

Anti-FANCD2 antibody [FI-17] used in Western Blot (WB). GTX25360

GTX25360 WB Image

WB analysis of HeLa cell lysate using GTX25360 FANCD2 antibody [FI-17].

Anti-FANCD2 antibody [FI-17] used in Western Blot (WB). GTX25360

GTX25360 WB Image

WB analysis of MCF-7 (lane 1) and HeLa (lane 2) cell lysate using GTX25360 FANCD2 antibody [FI-17].

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 429