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FANCD2 antibody [GT1223]

Recombinant antibody Orthogonal
Anti-FANCD2 antibody [GT1223] used in Western Blot (WB). GTX01531
Anti-FANCD2 antibody [GT1223] used in Western Blot (WB). GTX01531
Anti-FANCD2 antibody [GT1223] used in Western Blot (WB). GTX01531

Cat. No. GTX01531

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 GT1223

Isotype

 IgG

Application

 WB

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all FANCD2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
Not tested in other applications.

Calculated MW

164 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthesized peptide derived from human FANCD2.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

FA4,FACD,FAD,FAD2,FANCD,FANCD2,Fanconi anemia complementation group D2,FA complementation group D2

Cellular Localization

Nucleus

Background

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Database

Research Area

DATA IMAGES

Anti-FANCD2 antibody [GT1223] used in Western Blot (WB). GTX01531

GTX01531 WB Image

Orthogonal

Various whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with FANCD2 antibody [GT1223] (GTX01531) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
The observed M.W. is based on the publication: PMID: 25092648

Anti-FANCD2 antibody [GT1223] used in Western Blot (WB). GTX01531

GTX01531 WB Image

WB analysis of mouse testis tissue lysate using GTX01531 FANCD2 antibody [GT1223].
Dilution : 1:1000
Loading : 25 μg

Anti-FANCD2 antibody [GT1223] used in Western Blot (WB). GTX01531

GTX01531 WB Image

WB analysis of various samples using GTX01531 FANCD2 antibody [GT1223].
Dilution : 1:1000
Loading : 25 μg

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399