GeneTex
United States (US)

FANCD2 antibody

GTX30142_312_IHC-P_18121410_796.jpg
GTX30142_1344_WB_18121410_149.jpg
GTX30142_1345_WB_18121410_479.jpg

Cat No. GTX30142

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, FACS, IP
Reactivity Human, Mouse, Dog, Primate
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:10000 - 1:20000
IHC-P 2.5 - 5 μg/ml
FACS Assay dependent
IP 1:10 - 1:500
Not tested in other applications.

Calculated MW

166 kDa. ( Note )

Specificity/Sensitivity

This antibody is specific for FANCD2.
PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human FANCD2 fusion protein (N-terminal fragment). [Swiss-Prot #Q9BXW9]

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Fa Complementation Group D2,Fa-D2,Fa4,Facd,Fad,Fad2,Fancd,Fancd2

Cellular Localization

Nucleus

Background

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq]

Database

Research Area

DATA IMAGES
GTX30142_312_IHC-P_18121410_796.jpg

GTX30142 IHC-P Image

IHC-P analysis of human prostate tissue using GTX30142 FANCD2 antibody.

GTX30142_1344_WB_18121410_149.jpg

GTX30142 WB Image

WB analysis of HeLa cell lysate using GTX30142 FANCD2 antibody.

GTX30142_1345_WB_18121410_479.jpg

GTX30142 WB Image

WB analysis of HeLa cell lysate using GTX30142 FANCD2 antibody.
Dilution : 1:20000

REFERENCE
Application Reference
Package List Price ($)
$ 369